Typhoid with serious lower back pain This is called Typhoid Osteomyelitis of the lumbar spine Perhaps you are here because you have been diagnosed with Typhoid and after treatment, you still continue having serious lower back pain. Typhoid Osteomyelitis is more like a secondary form of typhoid fever caused by Salmonella typhi. Salmonella typhi is sensitive to ampicillin, ciprofloxacin, and ceftriaxone. However, the typhoid Osteomyelitis maybe resistant to one or some of these medications. According to research, typhoid has been reported to be resistant to ciprofloxacin in some people. Also, if the treatment doesn't last for a while with some of these medications the lower back pain (sometimes with stomach ache) could persist. You may notice some form of skin nodule in some part of your body as well. A case of a patient that was formerly reported according to PubMed: A 25-year-old Nepali man presented with a 20-day history of fever associated with a lower backache. Physical exam